Principle Investigator: Vincent Mok
Project Co-ordinator: Jessica Lau
Data Coverage: TAG ECG PPG
In the recent article on Nature Reviews[2] of Prof. Vincent Mok (Principal Investigator), he pointed out that small vessel diseases can play a critical role in delayed-onset poststroke dementia. Therefore, people who have survived stroke are at risk of developing dementia beyond the early poststroke period. Other studies suggest that midlife hypertension leads to increased cognitive decline, and could thus contribute to the development of vascular dementia, and even Alzheimer’s disease, in late life[3-4]. A longitudinal study over a 32-year period demonstrates that those who developed dementia, particularly vascular dementia, had a greater increase in systolic blood pressure (BP) from midlife to late life, followed by a greater decrease over the late life, and such association was significantly reduced in those taking anti-hypertensive medications [5].
This dataset contains the following characteristics: 100 cases with each case having up to 4 sets of the following measurements 5 sets of 1 min continuous blood pressure, ECG and PPG signal measurement by BIOPAC with 5 sets of corresponding mercury sphygmomanometer blood pressure readings and 10 min continuous blood pressure, ECG and PPG signal measurements. Follow-ups were done after 5 month in an ideal situation, however due to COVID-19, the follow ups were delayed. Time within each visit extended to 5-10 months. Data is not processed because the real world noise in the vital signs data is very essential to the development of practical monitoring algorithms.
[3] Qiu, C., Winblad, B. and Fratiglioni, L., 2005. The age-dependent relation of blood pressure to cognitive function and dementia. The Lancet Neurology,4(8), pp.487-499. [4] Gottesman, R.F., Schneider, A.L., Albert, M., Alonso, A., Bandeen-Roche, K., Coker, L., Coresh, J., Knopman, D., Power, M.C., Rawlings, A. and Sharrett, A.R., 2014. Midlife hypertension and 20-year cognitive change: the atherosclerosis risk in communities neurocognitive study. JAMA neurology,71(10), pp.1218-1227. [5] Stewart, R., Xue, Q.L., Masaki, K., Petrovitch, H., Ross, G.W., White, L.R. and Launer, L.J., 2009. Change in blood pressure and incident dementia. Hypertension,54(2), pp.233-240.